Identification and antitumor activity of a novel inhibitor of the NIMA-related kinase NEK6
نویسندگان
چکیده
منابع مشابه
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15 صفحه اولIdentification of the NIMA family kinases NEK6/7 as regulators of the p70 ribosomal S6 kinase
BACKGROUND The p70 S6 kinase, like several other AGC family kinases, requires for activation the concurrent phosphorylation of a site on its activation loop and a site carboxyterminal to the catalytic domain, situated in a hydrophobic motif site FXXFS/TF/Y, e.g.,Thr412 in p70 S6 kinase (alpha 1). Phosphorylation of the former site is catalyzed by PDK1, whereas the kinase responsible for the pho...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2018
ISSN: 2045-2322
DOI: 10.1038/s41598-018-34471-y